Comparison of extended to standard half-life recombinant factor VIII therapy in patients with hemophilia A on prophylactic therapy
نویسندگان
چکیده
منابع مشابه
Coagulation Therapy in Hemophilia A and its Relation to Factor VIII Inhibitor in Northeast of Iran
متن کامل
Detection of Factor VIII Inhibitors in Hemophilia A Patients
Background: Factor VIII administration to hemophilia A patients results in an immune response (inhibitor formation) which significantly complicates the therapy. The present study was performed to determine the prevalence of inhibitor development in hemophilia A patients receiving recombinant factor VIII therapy. Materials and Methods: This was an observational descriptive study. Clotting fac...
متن کاملPegylated, full-length, recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A.
Current management of hemophilia A includes prophylaxis with factor VIII (FVIII) replacement every 2 to 3 days. BAX 855, Baxalta's pegylated full-length recombinant FVIII (rFVIII), was designed to increase half-life and, thus, reduce the frequency of prophylactic infusions while maintaining hemostatic efficacy. BAX 855 was evaluated in previously treated patients with severe hemophilia A who we...
متن کاملcoagulation therapy in hemophilia a and its relation to factor viii inhibitor in northeast of iran
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متن کاملPostpartum Acquired Hemophilia Factor VIII Inhibitors and Response to Therapy
Postpartum-acquired hemophilia A is a rare and potentially severe complication of pregnancy caused by an autoantibody against factor VIII [1]. Acquired factor VIII deficiency is associated with autoimmune conditions, neoplastic diseases, drug hypersensitivity, and pregnancy. A retrospective study analyzed 51 published cases of postpartum factor VIII inhibitors, with regard to the outcome accord...
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ژورنال
عنوان ژورنال: Journal of Drug Assessment
سال: 2019
ISSN: 2155-6660
DOI: 10.1080/21556660.2019.1658327